XB-FEAT-6071789

flt1

This is the community wiki page for the gene flt1 please feel free to add any information that is relevant to this gene that is not already captured elsewhere in Xenbase

orthology and synteny notes for kdrl v. flt1

24APRIL2023

Despite suggestions from DIOPT Analysis, Xenopus kdrl genes are not orthologous with human ITL1. Note: There does not appear to be an orthologous mammalian gene for kdrl, and it only annotated in fishes and frogs. (ie it is missing in human and other mammals)

In Xtrop and in Zebrafish, kdrl is adjacent to chic1 and cdx4:

Xtr.chr8: amer1> ... arhgef9> ... kdrl> ... loc#> ... cdx4> ... chic1>

Xla.chr8L: amer1.L> ... arhgef9.L> ... kdrl.L> ... cdx4.L> ...

Dre.chr14: gdpd2< ... dlg3< ...tex11> ... kdrl> ... cdx4> ... chic1>

Whereas flt1 is flanked by slc46a3 and pan3 in all mammals, fish and frogs

Synteny across Xenopus is highly conserved for flt1: Xtrop: mtus2 > [LOC#9015(p) LOC#9139(unch) LOC(unch) LOC#9957] flt1> pan3< flt3>

Xla.L : mtus2.L > slc46a3.L flt1.L> pan3.L< flt3.L>

Xla.S : mtus2.S > slc46a3.S flt1.S> pan3.S< flt3.S>

Human CHR13: SLC46A3 ... FLT1...PAN3 ...FLT3

Dre.chr: slc46a3 ... flt1 ... pan3 .. flt3