XB-FEAT-486444: Difference between revisions
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=sox21= | =''sox21''= | ||
This is the community wiki page for the gene ''sox21'' please feel free to add any information that is relevant to this gene that is not already captured elsewhere in Xenbase | This is the community wiki page for the gene ''sox21'' please feel free to add any information that is relevant to this gene that is not already captured elsewhere in Xenbase. | ||
=different molecular functions of ''sox21.L'' and ''sox21.S''= | |||
Xenbase curators highly recommend you read this paper before embarking on experiments using sox21! | |||
'"Sox21 homeologs autoregulate expression levels to control progression through neurogenesis"' Damuth et al 2023. genesis DOI: 10.1002/dvg.23612 | |||
This study "aims to deepen our understanding of the spectrum of Sox21's function, by examining the differences between ''Sox21.L'' and ''Sox21.S'' function in the neural plate. Despite sharing high sequence similarity, these two Sox21 homeologs exhibit notable differences, particularly in the C-terminal region where Sox21.L and its evolutionarily derived homo- logs (e.g., those found in ''X. tropicalis'' – Xt, chick, and mouse) contain a stretch of alanines absent in Sox21.S and ancestral homologs (e.g., zebrafish and fugu). Interestingly, while ''Sox21.L'' and ''Xt.Sox21'' are highly similar, only ''Xt.Sox21'' represses eye formation. These observa- tions underscore the potentially divergent roles of these homeologs and warrant further investigation into their respective functions dur- ing neural development. Our findings reveal that although ''Sox21.L'' and ''Sox21.S'' are necessary and sufficient for neural differentiation, they exert their effects at different stages. Moreover, manipulating the levels of ''Sox21.S'' or ''.L'' disrupts the formation of primary neurons in the neural plate, as well as placode formation. Notably, we have identified a homeolog-specific negative feedback loop in ''Xenopus laevis'' that regulates the endogenous expression of sox21, ensuring proper regulation of neurogenesis. These findings shed light on the complex regulatory mechanisms that govern neurogenesis and emphasize the importance of precise control over the expression and activity of SoxB proteins as well as the intricate regulation of homeologs to ensure proper gene dosage." | |||
Latest revision as of 22:26, 18 August 2024
sox21
This is the community wiki page for the gene sox21 please feel free to add any information that is relevant to this gene that is not already captured elsewhere in Xenbase.
different molecular functions of sox21.L and sox21.S
Xenbase curators highly recommend you read this paper before embarking on experiments using sox21!
'"Sox21 homeologs autoregulate expression levels to control progression through neurogenesis"' Damuth et al 2023. genesis DOI: 10.1002/dvg.23612
This study "aims to deepen our understanding of the spectrum of Sox21's function, by examining the differences between Sox21.L and Sox21.S function in the neural plate. Despite sharing high sequence similarity, these two Sox21 homeologs exhibit notable differences, particularly in the C-terminal region where Sox21.L and its evolutionarily derived homo- logs (e.g., those found in X. tropicalis – Xt, chick, and mouse) contain a stretch of alanines absent in Sox21.S and ancestral homologs (e.g., zebrafish and fugu). Interestingly, while Sox21.L and Xt.Sox21 are highly similar, only Xt.Sox21 represses eye formation. These observa- tions underscore the potentially divergent roles of these homeologs and warrant further investigation into their respective functions dur- ing neural development. Our findings reveal that although Sox21.L and Sox21.S are necessary and sufficient for neural differentiation, they exert their effects at different stages. Moreover, manipulating the levels of Sox21.S or .L disrupts the formation of primary neurons in the neural plate, as well as placode formation. Notably, we have identified a homeolog-specific negative feedback loop in Xenopus laevis that regulates the endogenous expression of sox21, ensuring proper regulation of neurogenesis. These findings shed light on the complex regulatory mechanisms that govern neurogenesis and emphasize the importance of precise control over the expression and activity of SoxB proteins as well as the intricate regulation of homeologs to ensure proper gene dosage."