XB-FEAT-22069536

gene nomenclature & synteny

There are 3 named Xenopus cyp46a1 genes, a tadem duplication , cyp46a1.1, cyp46a1.2, cyp46a1.3, all on chr8 [Chr8:90631914..90931414 ], in this gene pattern ccdc85c< hhipl1> cyp46a1.1 cyp46a1.2, cyp46a1.3 mia2> fbxo33<

There is another cyp46a1-like gene duplication, also on Chr8, which we are giving the following names: cyp46a1.4, cyp46a1.5p (the p suffix as it is a pseudogene) and cyp46a1.6 .

These extra cyp46a1-like genes, seems to be a duplication of the duplication, and is only seen in the X.tropicalis and does not appear in Human, mouse or X. laevis.

synteny patterns:

Xtrop.Chr8:85600001..86207500 (607.5 Kb): spata7> ptpn21< zc3h14> eml5< ttc8> LOC100498621|ch24h/cyp46a1> LOC105948085[unch-pseudo]> LOC100145328|cyp46a1-like> foxn3< efcab11< tdp1>

Xla.chr8L: spata7.L> ptpn21.L< zc3h14.L> LOC108698703|eml5< ttc8.L> [ no duplicated cyp46a1 genes ] foxn3.L<

Xla.Chr8S: foxn3.S> LOC108699830|eml5> zc3h14.S< ptpn21.S> kcnk10.S> gpr65.S<

                                                                                                                                                          Human:      EML5<  TTC8<  [LOTS OF ENHANCERS] FOXN3<  EFCAB11< TDP1> KCNH13> 
                                                                                                                                                                                              MouseChr12:   Spata7> Ptpn21<  Zc3h14>   EML5<  TTC8<