XB-FEAT-22069536: Difference between revisions
| Line 1: | Line 1: | ||
= ''cyp46a1'' = | = ''cyp46a1'' = | ||
This is the community wiki page for the gene '' cyp46a1 '' please feel free to add any information that is relevant to this gene that is not already captured elsewhere in Xenbase. | |||
=summary for human CYP46A1 from NCBI= | |||
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This endoplasmic reticulum protein is expressed in the brain, where it converts cholesterol to 24S-hydroxycholesterol. While cholesterol cannot pass the blood-brain barrier, 24S-hydroxycholesterol can be secreted in the brain into the circulation to be returned to the liver for catabolism. [provided by RefSeq, Jul 2008] | |||
=gene nomenclature & synteny= | =gene nomenclature & synteny= | ||
Revision as of 10:00, 24 September 2024
cyp46a1
This is the community wiki page for the gene cyp46a1 please feel free to add any information that is relevant to this gene that is not already captured elsewhere in Xenbase.
summary for human CYP46A1 from NCBI
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This endoplasmic reticulum protein is expressed in the brain, where it converts cholesterol to 24S-hydroxycholesterol. While cholesterol cannot pass the blood-brain barrier, 24S-hydroxycholesterol can be secreted in the brain into the circulation to be returned to the liver for catabolism. [provided by RefSeq, Jul 2008]
gene nomenclature & synteny
There are 3 named Xenopus cyp46a1 genes, a tadem duplication , cyp46a1.1, cyp46a1.2, cyp46a1.3, all on chr8 [Chr8:90631914..90931414 ], in this gene pattern ccdc85c< hhipl1> cyp46a1.1 cyp46a1.2, cyp46a1.3 mia2> fbxo33<
There is another cyp46a1-like gene duplication, also on Chr8, which we are giving the following names: cyp46a1.4, cyp46a1.5p (the p suffix as it is a pseudogene) and cyp46a1.6 .
These extra cyp46a1-like genes, seems to be a duplication of the duplication, and is only seen in the X.tropicalis and does not appear in Human, mouse or X. laevis.
synteny patterns:
Xtrop.Chr8:85600001..86207500 (607.5 Kb): spata7> ptpn21< zc3h14> eml5< ttc8> LOC100498621|ch24h/cyp46a1> LOC105948085[unch-pseudo]> LOC100145328|cyp46a1-like> foxn3< efcab11< tdp1>
Xla.chr8L: spata7.L> ptpn21.L< zc3h14.L> LOC108698703|eml5< ttc8.L> [ no duplicated cyp46a1 genes ] foxn3.L<
Xla.Chr8S: foxn3.S> LOC108699830|eml5> zc3h14.S< ptpn21.S> kcnk10.S> gpr65.S<
Human: EML5< TTC8< [LOTS OF ENHANCERS] FOXN3< EFCAB11< TDP1> KCNH13>
MouseChr12: Spata7> Ptpn21< Zc3h14> EML5< TTC8<