XB-FEAT-962825: Difference between revisions
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This is the community wiki page for the gene ''orai2'' please feel free to add any information that is relevant to this gene that is not already captured elsewhere in Xenbase | This is the community wiki page for the gene ''orai2'' please feel free to add any information that is relevant to this gene that is not already captured elsewhere in Xenbase | ||
= | =nomenclature changes= | ||
07MAY2026 | |||
Orthology assertions are a critical get comparative genomics and are challenging component on a genomic annotation, and it has been a large part of Xenbase and NCBI curators work to make and improve these assertions for the ''Xenopus'' genomes. | |||
We recently realized that 2 genes were mis-annotated in the Xenopus v10 genomes: ''orai1'' and ''orai2''. | |||
Phylogenetic analysis, synteny and reciprocal BLAST confirm that these two genes are misidentified as each other: true human ORAI1 orthologs were misidentified as ''orai2'', and the true orthologs of human ORAI2 were misidentified as ''orai1''. | |||
The simple synteny maps on Xenbase (screen shots attached), and the phylograms below (the genes in the correct clades, but with the wrong gene symbol) confirm the error in gene name assignment. | |||
The renamed Xenopus orai1 genes, which are all on chromosome 1/1L/1S are now represented on XB-GENEPAGE-5781665: | |||
Xtr.orai1 Gene ID: 100380109 ENSXETG00000004483 | |||
Xla.orai1.L Gene ID: 108716807 | |||
Xla.orai1.S Gene ID: 108716807 | |||
The renamed Xenopus orai2 genes, which fall on chromosome 2/2L/2S, are now represent on XB-GENEPAGE- 962825. | |||
Xtr.orai2 Gene ID: 100125061 ENSXETG00000043670 | |||
Xla.orai2.L Gene ID: 108707681 | |||
Xla.orai2.S Gene ID: 403390 | |||
[[File:Screenshot 2026-05-07 at 3.18.00 PM|thumb|simple synteny map for Xenopus orai2 before renaming]] | |||
Revision as of 21:25, 7 May 2026
orai2
This is the community wiki page for the gene orai2 please feel free to add any information that is relevant to this gene that is not already captured elsewhere in Xenbase
nomenclature changes
07MAY2026
Orthology assertions are a critical get comparative genomics and are challenging component on a genomic annotation, and it has been a large part of Xenbase and NCBI curators work to make and improve these assertions for the Xenopus genomes.
We recently realized that 2 genes were mis-annotated in the Xenopus v10 genomes: orai1 and orai2.
Phylogenetic analysis, synteny and reciprocal BLAST confirm that these two genes are misidentified as each other: true human ORAI1 orthologs were misidentified as orai2, and the true orthologs of human ORAI2 were misidentified as orai1.
The simple synteny maps on Xenbase (screen shots attached), and the phylograms below (the genes in the correct clades, but with the wrong gene symbol) confirm the error in gene name assignment.
The renamed Xenopus orai1 genes, which are all on chromosome 1/1L/1S are now represented on XB-GENEPAGE-5781665:
Xtr.orai1 Gene ID: 100380109 ENSXETG00000004483
Xla.orai1.L Gene ID: 108716807
Xla.orai1.S Gene ID: 108716807
The renamed Xenopus orai2 genes, which fall on chromosome 2/2L/2S, are now represent on XB-GENEPAGE- 962825.
Xtr.orai2 Gene ID: 100125061 ENSXETG00000043670
Xla.orai2.L Gene ID: 108707681
Xla.orai2.S Gene ID: 403390