XB-FEAT-6036049

rbfox1

This is the community wiki page for the gene rbfox1 please feel free to add any information that is relevant to this gene that is not already captured elsewhere in Xenbase

nomenclature changes

undated change Human symbol has changed for Entrez Gene: 54715. from a2bp1 to rbfox1

09/24/2017 Human name has changed for Entrez Gene: 54715. From RNA binding protein, fox-1 homolog 1 to RNA binding fox-1 homolog 1

summary from NCBI

The Fox-1 family of RNA-binding proteins is evolutionarily conserved, and regulates tissue-specific alternative splicing in metazoa. Fox-1 recognizes a (U)GCAUG stretch in regulated exons or in flanking introns. The protein binds to the C-terminus of ataxin-2 and may contribute to the restricted pathology of spinocerebellar ataxia type 2 (SCA2). Ataxin-2 is the product of the SCA2 gene which causes familial neurodegenerative diseases. Fox-1 and ataxin-2 are both localized in the trans-Golgi network. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]