XB-FEAT-1217660
morc3
This is the community wiki page for the gene morc3 please feel free to add any information that is relevant to this gene that is not already captured elsewhere in Xenbase
nomenclature changes
10.05.2021
On review of latest genome annotation and associated gene models, it was discovered that there has been a morc3 gene duplication on Chromosome 2 in Xenopus, where X. tropicalis has 5 copies of the ‘morc3’ gene (one of which is considered a pseudogene), X. laevis.L has 3 copies, and X. laevis.S has 2 copies of the morc3 gene.
In both Xenopus species, and other vertebrates, the morc3 genes are inherited in a conserved gene block flanked by cldn14, chaf1 and dop1b.
Gene pattern:
Xtr v10: cldn14> chaf1b< … morc3< … LOC105945150< … LOC100490513< … LOC101730243 < …LOC108645749 … dopb1a"
Xla.L v9.2: chaf1b.L< … [ ] … morc3.2.L'< …LOC108707865< … LOC108707864< … [. ] ….dop1b.l<
Xla.S v9.2: dop1b.S> … LOC108709239> … morc3.S> … cldn14.S<
Applying gene nomenclature conventions, and considering 2 genes had already been assigned names ( morc3 [XB-GENEPAGE-1217660] and morc3.2 [XB-GENEPAGE-5995235]), the additional genes were numbered morc3.3 [XB-GENEPAGE-23659762] and morc3.4 [XB-GENEPAGE-23659766], and the pseudogene kept the ‘like’ suffix as applied by NCBI RefSeq. morc3l [XB-GENEPAGE-23659770] .
Previous LOC numbers are recorded as synonyms.
Note that X. laevis does not have morc3.L, morc3.3.S, morc3.4.S and that the pseudogene morc3l is only found in X. tropicalis.
All genes should be considered orthologs of human /vertebrate MORC3.
Human: Gene ID: 23515; Mouse gene ID: 338467; rat gene Id: 304074; Chicken Gene ID: 418513
summary from NCBI for human MORC3
This gene encodes a protein that localizes to the nuclear matrix and forms nuclear bodies via an ATP-dependent mechanism. The protein is predicted to have coiled-coil and zinc finger domains and has RNA binding activity. Alternative splicing produces multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Feb 2016]