Vismodegib

Vismodegib

Supplier: MedChem Express; catalog # HY-10440 "Vismodegib is an orally active hedgehog pathway inhibitor with an IC50 of 3 nM and also inhibits P-gp, ABCG2 with IC50 values of 3.0 μM and 1.4 μM, respectively."

Function: Shh (sonic hedgehog) signal pathway antagonist.

Phenotypic Effect: Vismodegib treatment of tapdpoles alters the development of the ear, hypaxial muscle, and indirectly, the Mauthner cells, through its interaction with the inner ear afferents. (ref PMID: 29030893)