Vismodegib

Supplier: MedChem Express; catalog # HY-10440 "Vismodegib is an orally active hedgehog pathway inhibitor with an IC50 of 3 nM and also inhibits P-gp, ABCG2 with IC50 values of 3.0 μM and 1.4 μM, respectively."

Function: Shh (sonic hedgehog) signal pathway inhibitor.

Phenotypic Effect: Vismodegib treatment of tapdpoles alters the development of the ear, hypaxial muscle, and indirectly, the Mauthner cells, through its interaction with the inner ear afferents. (ref PMID: 29030893)

PubChem CID: 24776445

Molecular Formula: C19H14Cl2N2O3S

Molecular Weight: 421.292 g/mol

InChI Key: BPQMGSKTAYIVFO-UHFFFAOYSA-N

Synonyms: 879085-55-9; GDC-0449; Erivedge; 2-chloro-N-(4-chloro-3-(pyridin-2-yl)phenyl)-4-(methylsulfonyl)benzamide