4-methylcyclohexane methanol (MCHM)

4-methylcyclohexane methanol (MCHM) is coal cleaning chemical. MCHM acts as a hydrotrope in vitro, changing the solubility and protein structure, and changes intracellular levels of a wide range of ions including calcium (Pupo et al 2019 [[1]]). The molecular target of MCHM is unknown, but biologically active hydrotropes change the liquid-liquid phase separation of transcription factors and RNA binding proteins (see references in Perfetto et al 2021 [[2]].)