XB-FEAT-22167183

This is the community wiki page for the gene ripk3l.1 please feel free to add any information that is relevant to this gene that is not already captured elsewhere in Xenbase

nomenclature updates

12.31.2019

This gene was renamed after a review by David Webb from the NCBI and Xenbase curators. It was changed from ripk3 gene 1 one to a ripk3-like gene 1 after a synteny analysis.

In Xenopus, the true ripk3 genes occur in a conserved order, in humans, frog, lizard and turtles, as nfatc4> ripk3> adcy4>, and is on Chromosome 1.

In X. tropicalis, this ripk3-like gene 1 is on currently placed on Chr2, and in X. Laevis, on Chromosome 8, although this needs more study to determine for sure. ( watch this space!)

It seems that the ripk3l.1 and ripk3l.2 genes do not occur in other vertebrates except the caecillian (Rhinatrema bivittatum), and may represent an amphibian-specific gene duplication event.

orthology

23SEPT2022

the human RIPK3 gene (gene ID 11035) has been removed from this gene page as it is not a true orthologs for ripk3-like gene 1 nor ripk3-like gene 2