XB-FEAT-991396

gprc6a.2

This is the community wiki page for the gene gprc6a.2 please feel free to add any information that is relevant to this gene that is not already captured elsewhere in Xenbase.

synteny & orthology

Although the conserved string of genes is small, gprc6a is consistently flanked by FAM162B.

DIOPT/EggNogg homology group comparison shows that the 2nd gprc6a in Xenopus is a true gprc6a , thus inferred it is a tandem duplicated gene, and is given the .2 /gene 2 suffix.

Xtrp Chr5: zup1 fam162b gprc6a.2. gprc6a

Xla Chr5L: fam162b.L gprc6a.2.L gprc6a.L zufsp.L

Human Chr6: 'FAM162B' GPRC6A RFX6

The human GPRC6A gene (GENEID:222545),and mouse (210198), rat (294394), chick (428620) and Zfish (494131) genes can be added to this gene page as an orthologs.

nomenclature changes

25APRIL2023

based on above syntney/ortholog assessment the Xenopus symbol name was changed from XB991396 [provisional:gprc6a] to gprc6a.2

Xenopus gene name changed from provisional orTholog of G-protein coupled receptor family C group 6 member A to G-protein coupled receptor family C group 6 member A gene 2.

Note that the X. laevis models on the gene page are from v9.2 genome and need to be updated to v10 models

PROTEIN ACCESSION USED IN DIOPT/EGGNOG ORTHOLOGY ASSERTIONS

G-protein coupled receptor family C group 6 member A [Xenopus tropicalis]

NCBI Reference Sequence: XP_002938346.1

>XP_002938346.1 G-protein coupled receptor family C group 6 member A [Xenopus tropicalis] MAVYGLAIILGTLLSGISCCLTPDDLIGAKSHGDIIIGGLFSVHGKMMNSPTGYPNIPAIQNCSGFEMQG FLQMLAMSHAIEMINNSPLIPGIRLGYEIYDTCSEVTMALSATMRLLSEFNSSEDNLKIKCNYTTYTPKV KAIIGDSYSEVSIAVARLLNTQLIPLVSHSSSAEILSDKFRFPTFLRTIPNDFHQTRAMAKLIHFSGWNW IGLIAMDDEYGRSALESFGAQSMKINVCIAFKHIIPAHLSDSTVQSKINKTIMTILRETRVNIIVVFLKP SLVIRLFKKVIQLNIQKTWIASDMWSAASTISSIPNIQRVGRVIGFTFKSGNMSPFLNYLKNLNSQHFEM NHLLDQYAWLLYHCPKVKYNELSSCISNYSKETPYDIKNRKGIFLKEDFLLESMQPGFVYSTQLAVTAIA YAIRNICSNRNCKDPDAFAPWELLQGLKTVNFTFDGRNIYFDSRGDANTGYDVLMWMVGDDGRIDITPVA EYDSQKDSFLFKNTEKENEFIRLKKIESTCSDQCKPGQMKKTSASLHTCCYECVACPENHHTNKSDMGYC LQCNNKTEWSPVNSSVCYNKDIKYLRWNDGFAIILLIVSFLGKGLIIAIALLFTKNFNTPVVKASGGILC YVILLSIFFSFVSAVFFIGKPEDFKCKVRQTLFGISFTVVVACIFLKSVKILLAFSFEPRVQRILRLLHK PFTLVFICTGIQVLICATWLVFWPPHMKENFSLPQTIIYECDEGSTIAFSVMLVYIAVLAFICFIFAFKG RKLPENYNEAKFITFGMLIYSIAWITFIPIYATTFGIYLPAVEMIVILISSYGILTCTFFPKCYIILYKQ DSNTKTAFLKMIYKYSSKSASNLTISQASSSSVVLESSSSASDVYVSTTLSCISNTFSFHERLVTTDIPS SHTGLPTRKRLSSI