XB-FEAT-877260

rergl.2

This is the community wiki page for the gene rergl.2 please feel free to add any information that is relevant to this gene that is not already captured elsewhere in Xenbase

nomenclature changes

25APRIL2023 Xenopus gene name changed from rergl2 (provisional) to rergl.2 (provisional).

synteny and orthology

25April2023

There are 3 'RERG' family genes annotated inv10 genome for Xenopus tropicalis:

1) rerg RAS like estrogen regulated growth inhibitor on chr3/3L. XB-GENEPAGE-489596

2) rergl RERG/RAS-like on Chr3/3L/3S XB-GENEPAGE-6037389

3) rergl2 RAS like estrogen regulated growth inhibitor like 2 (provisional) on Chr4/4L [XB-GENEPAGE-877260] where its is flanked by mrpl21, ighmbp2, syt12 ptdss2 downstream (the upstream the genes are uncharacterized)

Based on pattern of synteny, the rergl2 X. tropicalis gene (GeneID:100145332) is 'NOT' the true ortholog of human RERG nor RERGL. It seems to be a Xenopus and possible amphibian species gene very similar to RERGL, so the named is provisionally here with the '2' suffix, assuming it is a unique rergl gene, but not a .2 as this is used for tandem duplications.