XB-FEAT-29077890
cupin1.2
nomenclature changes
09FEB2023
There's a complex evolutionary history of a set of genes including those previously called DYNAP in the region between C18orf54 and RAB27b.
After review from HGNC and NCBIs refSeq Team,(JIRA HGNC-78), LOC112441476 (cow), LOC106780934 (horse) LOC116186940 (cat) and LOC102154335 (dog) were named CUPIN1.
NB:L monkeys and apes have lost the CUPIN1 gene.
In Xenopus, there is cupin1 found on chromosome 1/1L/1S, and an adjacent duplicated gene cupin1.2 on chromosome 1/1L
CUPIN1 is the name decided on to use for the ancestral, vertebrate, 9-exon gene with an N-terminal CLLAC domain and a C-terminal bicupin_oxalic domain (or two CUPIN_1 domains).
CUPIN1 encodes roughly 470 aa. The CUPIN1 gene is lost in human, mouse, and a variety of related primates and rodents. The DYNAP gene is mammal-specific and is sort of a remnant of the CUPIN1 gene that involved duplication as well as insertion of various exons or elements from elsewhere in the genome.
synteny patterns
Xtr chr1: ccdc68> ... rab27b> ... cupin1.2< ... LOC116408353(lnRNA)> ... cupin1< ... c1h18orf54< ...stard6<
Xla chr1L: ccdc68.L> ... rab27b.L> ... cupin1.2.L< ... cupin1< ... c1h18orf54.L< ...stard6.L<
Xla chr1S:ccdc68.S> ... rab27b.S> ... cupin1< ... c1h18orf54.S< ...stard6.S<
cupin1.2 gene IDs:
Xtr cupin1.2 NCBI gene ID:100485626
Xla cupin1.2.L NCBI gene ID:108695867