XB-FEAT-988106

adam13

This is the community wiki page for the gene adam13 please feel free to add any information that is relevant to this gene that is not already captured elsewhere in Xenbase.

background to resolving adam13 v adam33 names

The protein ADAM13 (Alfandari et al., 1997 [1] is related to human ADAM33 but the sequences have diverged sufficiently that the two proteins cannot functionally replace each other.

Orthology (and thus accurate nomenclature) is being assessed by Xenbase and NCBI's ref seq and the HGNC.

ADAM13 is a cell surface metalloprotease that binds to its substrate via its cystein rich domain ([Gaultier et al., 2002][2]; [Smith et al., 2002][3]). ADAM13 binds and cleave fibronectin (Alfandari et al., 2001[4]), Cadherin-11 (McCusker et al., 2009[5]), PAPC (Cousin et al., 2011[6]) and ephrinB (Wei et al., 2011[7]).

ADAM13 also cleaves itself within its cystein rich domain (Gaultier et al., 2002[8]). This cleavage can be followed by a cleavage by gama-secretase that release the cytoplasmic domain. The ADAM13 cytoplasmic domain translocates into the nucleus where it regulates gene expression to promote cranial neural crest cell migration (Cousin et al., 2011[9]).

The cytoplasmic domain of ADAM13 interacts with multiple SH# containing proteins including PACSIN-2 which negatively regulates its proteolytic activity (Cousin et al., 2000 [10]).