XB-FEAT-6538722

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esr-5

This is the community wiki page for the gene esr-5 please feel free to add any information that is relevant to this gene that is not already captured elsewhere in Xenbase.

annotation notes

04.04.2024 The orthology of these Xenopus esr-5 genes is unassigned as of 4.4.24, yet a quick assessment of the protein sequence in EggNog6.0, it matches the Hes7 orthology group (in ~8k proteins and 1165 species).

InterPro domain assessment shows the protein contains a bHLH-O_HES7 and orange_5 domains , which also support idea that these are Hes7 proteins and need renaming.

InterPro GO terms

Biological Process

regulation of DNA-templated transcription (GO:0006355)

Molecular Function

DNA binding (GO:0003677)

protein dimerization activity (GO:0046983)

Cellular Component

None

protein sequences

NB: the Xtrop and Xlaevis protein sequences are almost identical

>uncharacterized protein LOC100135364 [Xenopus tropicalis] mpdmeysdtfpsrkilkpvvekqrrdrinrsleemrvlllkltgnqklqnpkmekaeilelaviyirnvthmkthdasqwvspaeklylsgfrecldrtedfiseispkaravfldnlqthlqqrlhfptqvglggpgrdheedlmssgnglspimdysisrddlslctppsslssesgspqqwlpasppnqheqapfyiwrpwp


>>XP_018109262.1 PREDICTED: transcription factor HES-7 [Xenopus laevis] MPDMEYSDTFPSRKILKPVVEKQRRDRINRSLGEMRILLFQLTGNQKLQNPKMEKAEILELAVIYIRNVTRMKTHDPNKWASPAEKMYVSGFRECLDRTEDFISEISPKARAVFLDNLQTHLQQRLLLPQQVGGPGGDHEEDLMSNGSELSPIMDYSISRDELSLCTPSSSLGSESGSPPAWLPSSPPNPHEQPPLYIWRPWP