XB-FEAT-480646

cyp21a2

This is the community wiki page for the gene cyp21a2 please feel free to add any information that is relevant to this gene that is not already captured elsewhere in Xenbase.

nomenclature changes

5.17.21

Xenopus gene name updated to follow human gene and indicate gene duplicated: from cytochrome P450 family 21 subfamily A member 2 to cytochrome P450 family 21 subfamily A member 2, gene 1.

9.20.2024

Xenopus gene symbol changed from cyp21a2 .1 to cyp21a2

summary for human CYP21A2 from NCBI

This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and hydroxylates steroids at the 21 position. Its activity is required for the synthesis of steroid hormones including cortisol and aldosterone. Mutations in this gene cause congenital adrenal hyperplasia.