XB-FEAT-964428

pgc.4

This is the community wiki page for the gene pgc.4 please feel free to add any information that is relevant to this gene that is not already captured elsewhere in Xenbase.

Nomenclature changes

30SEPT2024

Xenopus gene symbol changed from XB964428 to pgc.4

Xenopus gene name changed from provisional ortholog of progastricsin to progastricsin gene 4

annotation notes

30.09.2024

Add X. laevis v10 gene model XBXL10_1g7085 to this gene page based on synteny, but at this point the X. laevis gene is officially 'uncharacterised'.

Note that there are 4 duplicates of pgc genes on chromosome2 in v10 X. tropicalis genome annotation, which we have numbered, from right to left, flanked by frs3 and tfeb. The synteny matches that of X.laevis S, as each model was already characterized by NCBI as a provisional orthology of pgc/progasticsin. The 4 x genes in X. laevis were however 'uncharacterised' and have been provisionally added to the Xenbase pgc.1-.4 gene pages solely based on synteny ( this is to ideal - BLAST and MSA needs to be done as well) . The Xlaevis.: genes all seem very truncated in comparison to .S and Xtrop models, although they are also all protein coding, so this may be a case where the S sub genome gene are functional and L genes less so.

Synteny

Xtrop. Chr2: frs3> pgc.4> pgc.3> pgc.2> pgc.1> MGC108380> tfeb>

Xla. 2L: frs3.L> pgc.4.L> pgc.3.L> pgc.2.L> pgc.1.L> LOC108708147(sorting nexin 18 like)< LOC121399969(PSEUDO)< LOC108708144(MAPK13)<

Xla.2S: frs3.S> pgc.4.S> pgc.3.S> pgc.2.S> pgc.1.S> tfeb.S>. LOC108709461.S(MYOD inhibitor)< foxp4.S<