XB-FEAT-6043649

clec4m

This is the community wiki page for the gene clec4m please feel free to add any information that is relevant to this gene that is not already captured elsewhere in Xenbase

nomenclature updates

01MAY2020

Xenopus gene name changed for Entrez gene ID:108696088 from from “CD209 antigen-like protein A” to “C-type lectin domain family 4 member M”

Xenopus gene symbol changed for Entrez gene ID:108696088 from “CD209 ” to “clec4m”

summary from NCBi for human CLEC4M

This gene encodes a C-type lectin that functions in cell adhesion and pathogen recognition. This receptor recognizes a wide range of evolutionarily divergent pathogens with a large impact on public health, including tuberculosis mycobacteria, and viruses including Ebola, hepatitis C, HIV-1, influenza A, West Nile virus and the SARS-CoV acute respiratory syndrome coronavirus. The protein is organized into four distinct domains: a C-terminal carbohydrate recognition domain, a flexible tandem-repeat neck domain of variable length, a transmembrane region and an N-terminal cytoplasmic domain involved in internalization. This gene is closely related in terms of both sequence and function to a neighboring gene, CD209 (Gene ID: 30835), also known as DC-SIGN. The two genes differ in viral recognition and expression patterns, with this gene showing high expression in endothelial cells of the liver, lymph node and placenta. Polymorphisms in the tandem repeat neck domain are associated with resistance to SARS infection. [provided by RefSeq, May 2020]