XB-FEAT-488139

ocm2

This is the community wiki page for the gene ocm2 please feel free to add any information that is relevant to this gene that is not already captured elsewhere in Xenbase

nomenclature changes

This gene renamed from ocm2 to ocm1 on 7/1/2019. Since humans duplicated the ancestral gene with this sequence, this gene is equally orthologous to human ocm1 (ocm) and ocm2. KAB selected ocm1 to help disambiguate orthologues in chicken in the future

This gene is part of the ocm locus which has 3 ancestral genes. Placental mammals only retained one, but humans duplicated with a chomosomal break exactly at the ocm gene, resulting in two closely related genes named OCM1 and OCM2. KAB unilaterally renamed this more ancestral gene as ocm1 to facilitate proper orthology between genes of species which retain more paralogs from the original locus than human has. These proposed gene names are under review by HGNC. However, this gene is not properly homologous to OCM1 nor OCM2 in human.

The ancestral locus, 5' to 3' is proposed to be OCM3 -> OCM4 -> OCM1

X. tropicalis (as well as coelocanth and bony fish) have larger tandem arrays of OCM genes, specifically the OCM4 paralogues

The gene symbols used for the tandem genes in this cluster are correct according to NCBI/Ref Seq (see discussion logged RSCOM-81). <CCZ1 <OCM1 <OCM4.6 <OCM4.5 <OCM4.4 <OCM4.3 <OCM4.2 <OCM4.1 <OCM3 LMTK2>

REfseq aggree with us "Xenbase correctly names the gene adjacent to CCZ1 as OCM1 and ... properly name the gene adjacent to LMTK2 as OCM3".

OCM3 has no orthologs in placental mammals but has orthologs in chicken NP_001007478.1, platypus XP_001512095.1, and opossum XP_007498332.1.

The single OCM3 gene is related to a tandem cluster of genes Xenbase has named OCM4.1-OCM4.6.

OCM4 has no orthologs in mammals but is orthologous to chicken XP_025011090.1.

This gene should not be renamed unless instructed by HGNC