Y27632

Description

"Y-27632 is highly potent, cell-permeable, selective ROCK (Rho-associated coiled coil forming protein serine/threonine kinase) inhibitor. Ki = 140 nM for p160ROCK. Y-27632 also inhibits ROCK-II with equal potency. The inhibition is competitive with respect to ATP."

• -Sigma Product Description

Y27632 structure, photo from Sigma-Aldrich

Genes Affected

• rock1
• rock2

Suppliers

• Sigma
• Tocris

Usage Notes

10uM in culture

References

• Pubchem
• Langdon et al., 2012
• Zhou

>28 Xenbase articles contain a reference to Y27632 or Y-27632 according to textpresso

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