SB431542

Description

"Potent and selective inhibitor of the transforming growth factor-β (TGF-β) type I receptor activin receptor-like kinase ALK5 (IC50 = 94 nM), and its relatives ALK4 and ALK7. Suppresses TGF-β-induced proliferation of human osteosarcoma cells. Stimulates proliferation, differentiation and sheet formation of ESC-derived endothelial cells."

• -Tocris Product Description

SB-431542 structure, photo from Sigma-Aldrich

Genes Affected

• ALK4 is a synonym for acvr1b
• ALK5 is a synonym for tgfbr1
• ALK7 is a synonym for acvr1c

Suppliers

• Tocris
• Apex
• Cayman
• Sigma
• abcam
• Selleckchem

References

• Ho et al., 2006
• Chiu 2014
• Pubchem

>23 Xenbase articles contain a reference to SB-431542 according to textpresso

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