XB-FEAT-980096

rigi

This is the community wiki page for the gene rigi please feel free to add any information that is relevant to this gene that is not already captured elsewhere in Xenbase Italic text.

summary for human RIGI from NCBI

DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases which are implicated in a number of cellular processes involving RNA binding and alteration of RNA secondary structure. This gene encodes a protein containing RNA helicase-DEAD box protein motifs and a caspase recruitment domain (CARD). It is involved in viral double-stranded (ds) RNA recognition and the regulation of the antiviral innate immune response. Mutations in this gene are associated with Singleton-Merten syndrome 2. [provided by RefSeq, Aug 2020]

Annotation notes from NCBI

Note: Human RARRES3 (Gene ID: 5920) and Human DDX58 (Gene ID: 23586) share the RIG1/RIG-1 alias in common. RIG1 is a widely used alternative name for DExD/H-box helicase 58 (DDX58), which can be confused with the retinoic acid receptor responder 3 (RARRES3) gene, since they share the same alias. [22 Jan 2019] Note: This gene has been reviewed for its involvement in coronavirus biology, and is involved in immune response or antiviral activity.