XB-FEAT-5751696

guca1al

This is the community wiki page for the gene guca1al please feel free to add any information that is relevant to this gene that is not already captured elsewhere in Xenbase.

nomenclature changes

01/12/2016 Human name has changed for Entrez Gene: 2978. From guanylate cyclase activator 1A (retina) to guanylate cyclase activator 1A

07.09.2018

Human name has changed for Entrez Gene: 2978. guanylate cyclase activator 1A like to guanylate cyclase activator 1A

2018.11.13

Xenopus gene symbol has changed for genepage ID: 5751696 From guca1a to guca1al

This gene was renamed to guca1a-like, and its gene symbol appended with an "l".

A true syntenic 'guca1a' was discovered, and an accompanying genepage created (XB-GENEPAGE-22061923).

This genepage should be linked to human GUCA1A unless further evidence links it to another/different family member.

gene symbol and name should NOT be changed back to guca1a per KAB/Xenbase curatorial team.

29.11.2022 further investigation via EggNOG orthology database confirms guca1al protein NP_001072507 as similar to GUCA1A type genes by homology.

Furthermore, top BLASTp:Human search results for guca1al (XB-GENEPAGE-5751696) are GUCA1A protein isoforms, supporting that guca1al is a GUCA1A gene despite no shared synteny with human.

synteny

Synteny across human and X. tropicalis is not conserved, so we can not identify a better human ortholog for this gene, other than GUCA1A

Hsa chr3: FBX040> … HCLS1< …[2x RNApsuedogenes<] … GOLGB1< … IQCB1< …EAF2>

Xtr ch3: golgb1< ...guca1al> … tcaf2> tcaf1> tcaf#(1.2 or 3) … znf585b< …

Xtr ch2 fbxo40 …

Xtr ch9 : adcy5> … iqcb1< … eaf2> …

Also known as

COD3; GCAP; GUCA; GCAP1; GUCA1; CORD14; C6orf131

Summary from NCBI

This gene encodes an enzyme that plays a role in the recovery of retinal photoreceptors from photobleaching. This enzyme promotes the activity of retinal guanylyl cyclase-1 (GC1) at low calcium concentrations and inhibits GC1 at high calcium concentrations. Mutations in this gene can cause cone dystrophy 3 and code-rod dystrophy 14. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]