XB-FEAT-5802443

cyp46a1

This is the community wiki page for the gene cyp46a1 please feel free to add any information that is relevant to this gene that is not already captured elsewhere in Xenbase

nomenclature changes

01/12/2016 Human name has changed for Entrez Gene: 10858. From cytochrome P450, family 46, subfamily A, polypeptide 1 to cytochrome P450 family 46 subfamily A member 1

gene nomenclature & synteny

There are 3 named Xenopus cyp46a1 genes, a tadem duplication , cyp46a1.1, cyp46a1.2, cyp46a1.3, all on chr8 [Chr8:90631914..90931414 ], in this gene pattern ccdc85c< hhipl1> cyp46a1.1 cyp46a1.2, cyp46a1.3 mia2> fbxo33<

There is another cyp46a1-like gene duplication, also on Chr8, which we are giving the following names: cyp46a1.4, cyp46a1.5p (the p suffix as it is a pseudogene) and cyp46a1.6 .

These extra cyp46a1-like genes, seems to be a duplication of the duplication, and is only seen in the X.tropicalis and does not appear in Human, mouse or X. laevis.

synteny patterns:

Xtrop.Chr8:85600001..86207500 (607.5 Kb): spata7> ptpn21< zc3h14> eml5< ttc8> LOC100498621|ch24h/cyp46a1> LOC105948085[unch-pseudo]> LOC100145328|cyp46a1-like> foxn3< efcab11< tdp1>

Xla.chr8L: spata7.L> ptpn21.L< zc3h14.L> LOC108698703|eml5< ttc8.L> [ no duplicated cyp46a1 genes ] foxn3.L<

Xla.Chr8S: foxn3.S> LOC108699830|eml5> zc3h14.S< ptpn21.S> kcnk10.S> gpr65.S<

                                                                                                                                                          Human:      EML5<  TTC8<  [LOTS OF ENHANCERS] FOXN3<  EFCAB11< TDP1> KCNH13> 
                                                                                                                                                                                              MouseChr12:   Spata7> Ptpn21<  Zc3h14>   EML5<  TTC8<