XB-FEAT-481046

stat3

This is the community wiki page for the gene stat3 please feel free to add any information that is relevant to this gene that is not already captured elsewhere in Xenbase

gene expression

source:talk by Mafalda Loreti, in the De-Li Shi and Clemance Carron labs, EAC July 30th, Rennes, France.

stat3.1 ( and stat3.2) are mainly activated during gastrulation, and is regulated by dscr6 , which inhibits methyaltion.

stat3 methylation is involved in axis formation ( activation causes ventralization, and inactivation causes dorsalization of Xenopus embryos)

ezh2 positively regulates stat3 methylation.

summary from NCBI

The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators.

This protein is activated through phosphorylation in response to various cytokines and growth factors including IFNs, EGF, IL5, IL6, HGF, LIF and BMP2. This protein mediates the expression of a variety of genes in response to cell stimuli, and thus plays a key role in many cellular processes such as cell growth and apoptosis. The small GTPase Rac1 has been shown to bind and regulate the activity of this protein. PIAS3 protein is a specific inhibitor of this protein. Mutations in this gene are associated with infantile-onset multisystem autoimmune disease and hyper-immunoglobulin E syndrome. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Sep 2015]

nomenclature changes

04/22/2016 Human name has changed for Entrez Gene: 6774. From signal transducer and activator of transcription 3 (acute-phase response factor) to signal transducer and activator of transcription 3