XB-FEAT-968211

mgat4a

This is the community wiki page for the gene mgat4a please feel free to add any information that is relevant to this gene that is not already captured elsewhere in Xenbase

summary

This gene encodes a key glycosyltransferase that regulates the formation of tri- and multiantennary branching structures in the Golgi apparatus. The encoded protein, in addition to the related isoenzyme A, catalyzes the transfer of N-acetylglucosamine (GlcNAc) from UDP-GlcNAc in a beta-1,4 linkage to the Man-alpha-1,3-Man-beta-1,4-GlcNAc arm of R-Man-alpha-1,6(GlcNAc-beta-1,2-Man-alpha-1,3)Man-beta-1,4-GlcNAc-beta-1,4-GlcNAc-beta-1-Asn. The encoded protein may play a role in regulating the availability of serum glycoproteins, oncogenesis, and differentiation. [provided by RefSeq, Jul 2008]

nomenclature changes

06.26.2018 Human name has changed for Entrez Gene: 11282. From mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme B to alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase B.