XB-FEAT-29072457

anln2

This is the community wiki page for the gene anln2 please feel free to add any information that is relevant to this gene that is not already captured elsewhere in Xenbase.

gene annotation, nomenclature and synteny

Two different genes were annotated as anillin/anillin actin binding protein, 'anln' in Xenopus v10 genomes

1) Xtr.anln (GeneID:100491625; ENSXETG00000000343) and Xla.anln.L (GeneID:398569) genes on Chr6/6L, with synteny conserved in mammals, frogs, chicken.

Based on synteny with mamals & chick, these are considered the true ANLN orthologs, and thus should keep the anln gene symbol.

Synteny patterns

Xtropchr6: elmo1> aoah> LOC100491625< matcap2> eepd1<

Xla.Chr6L: elmo1.L> aoah.L> anln.L< matcap2.L> eepd1.L<

spinytoadchr5: eepd1> LOC> anln> aoah< elmo1<

HumanChr7: MATCAP2<* ANLN>* [ENHACERS] AOAH< NPM1P18> ELMO1<

ChickChr2: elmo1> aoah> *anln< * kia0895> eepd1< septin 7<

Note that anln in fish doesn't follow the syntentic pattern:

DanioChr19: rnf19b< ak2< *anln< *ptp2a2b< col18a2

2) Xtr.anln2 (GeneID:100329114; ENSXETG00000039411) and Xla.anln2.L (GeneID:108714167) are on chr 4/4L, where synteny is conserved acrosss Xenopus, other frogs and fishes, but seems it is missing/lost in mammals and birds ( according to Genomicus) .

A new gene pages for the Chr4 genes and call them anln2 with NCBI RefSeq team and HGNC approval.

synteny:

Xtropchr4: matcap1< exoc3L1< anln2< tmem208< usp1> elmo3> e2f4<

Xlachr4L: exoc3l1.L< LOC108714167< tmem208.L< usp1.L> elmo3.L< e2f4.L<

XlaChr4S:(rv) matcap1.S< LOC121393288> tmem208.S< usp1.S> e2f4.S>

whereas in mammals.....

Humanchr16: MATCAP1< EXOC3L1< LOC[ENHANCER]> E2F4> ELMO3> FBXL9P< TMEM208> FHOD1<

MouseCHR8: hsf4> nol3> matcap1< exoc3l< e2f4> elmo3> fbx19< tmem208> fhod1<