XB-FEAT-1018908

opn5

This is the community wiki page for the gene opn5 please feel free to add any information that is relevant to this gene that is not already captured elsewhere in Xenbase

notes from XB-ART-57377

"Only one neuropsin gene (opn5) exists in mammals, where it is involved in retinal and circadian photoentrainment to ultraviolet light [59,60]. opn5 is expressed by cells deep in the Xenopus brain that regulate a rhythmic swimming activity responsive to ambient light [61]. Additional neuropsin genes are present in several vertebrate species [13], all of which we found are duplicated in the X. laevis genome (opn6-8) (Fig. 2A). Interestingly, we also detected two genes phylogenetically related to opn6 and opn7 located on chromosome 8 L (gene numbers 108,698,982) and 6 L (gene number 108718575), which we named opn6a and opn7b, respectively, following the Xenopus nomenclature guidelines (Fig. 2A). RT-PCR analysis indicates that opn5 and opn6b are the only neuropsins expressed by the PC (Fig. 4A), though considerable effort to identify mRNA expression for these genes by ISH was unsuccessful."

Source: Source: Bertolesi et al 2020. The regulation of skin pigmentation in response to environmental light by pineal Type II opsins and skin melanophore melatonin receptors. Journal of Photochemistry and Photobiology B: BiologyVolume 212, November 2020, 112024