XB-FEAT-5840788

nat8.1

This is the community wiki page for the gene nat8.1 please feel free to add any information that is relevant to this gene that is not already captured elsewhere in Xenbase.

nomenclature changes

NOV 2019

This gene represents one of 9 duplicated ‘nat8’ genes identified by Xenbase during analysis “Xenopus” v9/10 genome annotation, all on Chromosome 1 in “X. tropicalis” and “X. laevis”, and is true ortholog of the human NAT8B gene.

Note that not all duplications are present in “X. tropicalis”, and “X. laevis” does not always have both .L and .S homeologs.

06.20.2020

Human symbol has changed for genepage ID: 5840788 From nat8.1 to NAT8B, recognizing that in humans, NAT8B is likely a psuedogene, adjacent to NAT8 ( see NCBI summary below). It is not clear if nat8.1 is a psuedogene in Xenopus at this time, so Xenopus name will remain unchanged unti further data is assessed.

Summary for human NAT8B from NCBI

The protein encoded by this gene is highly similar to the N-acetyltransferase 8 (NAT8) gene product, which is a kidney and liver protein with homology to bacterial acetyltransferases involved in drug resistance. This gene is localized on chromosome 2 in the vicinity of the NAT8 gene and may represent a pseudogene of NAT8. This gene contains two polymorphic nonsense mutations that disrupt the active site of the protein. The full-length product of this gene contains a complete acetyltransferase domain and is identical in length to NAT8. [provided by RefSeq, Jul 2008]

Annotation information

Note: This gene is named as a pseudogene because some transcripts contain two stop codons, the latter one destroying the active site of the enzyme (PubMed 16395595). Because some variants exist without the stop codons, the NCBI RefSeq Project treats this as a protein-coding gene. [13 Feb 2013]