XB-FEAT-5918937

mllt11

This is the community wiki page for the gene mllt11 please feel free to add any information that is relevant to this gene that is not already captured elsewhere in Xenbase

nomenclature changes

08/03/2015 Human name has changed for Entrez Gene: 10962. From myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 to myeloid/lymphoid or mixed-lineage leukemia; translocated to, 11

05/15/2017 Human name has changed for Entrez Gene: 10962. From myeloid/lymphoid or mixed-lineage leukemia; translocated to, 11 to MLLT11, transcription factor 7 cofactor

summary from Entrez gene

In humans, the gene variously symbolized ALL1, HRX, or MLL located on 11q23 has been demonstrated to be fused with a number of translocation partners in cases of leukemia. t(1;11)(q21;q23) translocations that fused the MLL gene to a gene on chromosomal band 1q21 in 2 infants with acute myelomonocytic leukemia have been demonstrated. The N-terminal portion of the MLL gene is critical for leukemogenesis in translocations involving band 11q23. This gene encodes 90 amino acids. It was found to be highly expressed in the thymus but not in peripheral lymphoid tissues. In contrast to its restricted distribution in normal hematopoietic tissue, this gene was expressed in all leukemic cell lines tested. [provided by RefSeq, Jul 2008]