XB-FEAT-853932

ptpn22

This is the community wiki page for the gene ptpn22 please feel free to add any information that is relevant to this gene that is not already captured elsewhere in Xenbase

nomenclature changes

04/22/ 2016

Human name has changed for Entrez Gene: 26191. From protein tyrosine phosphatase, non-receptor type 22 (lymphoid) to protein tyrosine phosphatase, non-receptor type 22

05.13.19

Human name has changed for Entrez Gene: 26191. From protein tyrosine phosphatase, non-receptor type 22 to protein tyrosine phosphatase non-receptor type 22

Summary from NCBI for human PTPN22

This gene encodes of member of the non-receptor class 4 subfamily of the protein-tyrosine phosphatase family. The encoded protein is a lymphoid-specific intracellular phosphatase that associates with the molecular adapter protein CBL and may be involved in regulating CBL function in the T-cell receptor signaling pathway. Mutations in this gene may be associated with a range of autoimmune disorders including Type 1 Diabetes, rheumatoid arthritis, systemic lupus erythematosus and Graves' disease. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Mar 2009]