XB-FEAT-876538

nfatc4

This is the community wiki page for the gene nfatc4 please feel free to add any information that is relevant to this gene that is not already captured elsewhere in Xenbase

nomenclature changes

04/22/ 2016

Human name has changed for Entrez Gene: 4776. From nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4 to nuclear factor of activated T-cells 4

12/18/2017

Human name has changed for Entrez Gene: 4776. From nuclear factor of activated T-cells 4 to nuclear factor of activated T cells 4

NCBI Summary

This gene encodes a member of the nuclear factor of activated T cells (NFAT) protein family. The encoded protein is part of a DNA-binding transcription complex. This complex consists of at least two components: a preexisting cytosolic component that translocates to the nucleus upon T cell receptor stimulation and an inducible nuclear component. NFAT proteins are activated by the calmodulin-dependent phosphatase, calcineurin. The encoded protein plays a role in the inducible expression of cytokine genes in T cells, especially in the induction of interleukin-2 and interleukin-4. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]