XB-FEAT-921336

porcn

This is the community wiki page for the gene porcn please feel free to add any information that is relevant to this gene that is not already captured elsewhere in Xenbase

nomenclature changes

05/21/2017 Human name has changed for Entrez Gene: 64840. From porcupine homolog (Drosophila) to porcupine O-acyltransferase

Summary from RefSeq

This gene belongs to the evolutionarily conserved porcupine (Porc) gene family. Genes of the porcupine family encode endoplasmic reticulum proteins with multiple transmembrane domains. Porcupine proteins are involved in the processing of Wnt (wingless and int homologue) proteins. Disruption of this gene is associated with focal dermal hypoplasia, and the encoded protein has been implicated in cancer. Multiple alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Aug 2013]