XB-FEAT-984478

bcl6

This is the community wiki page for the gene bcl6 please feel free to add any information that is relevant to this gene that is not already captured elsewhere in Xenbase

nomenclature changes

12/18/2017

Human name has changed for Entrez Gene: 604. From B-cell CLL/lymphoma 6 to B cell CLL/lymphoma 6

NCBI Summary

The protein encoded by this gene is a zinc finger transcription factor and contains an N-terminal POZ domain. This protein acts as a sequence-specific repressor of transcription, and has been shown to modulate the transcription of STAT-dependent IL-4 responses of B cells. This protein can interact with a variety of POZ-containing proteins that function as transcription corepressors. This gene is found to be frequently translocated and hypermutated in diffuse large-cell lymphoma (DLCL), and may be involved in the pathogenesis of DLCL. Alternatively spliced transcript variants encoding different protein isoforms have been found for this gene. [provided by RefSeq, Aug 2015]