XB-FEAT-952393

yap1

This is the community wiki page for the gene yap1 please feel free to add any information that is relevant to this gene that is not already captured elsewhere in Xenbase.

gene expression notes

source: Muriel Perron talk, EAC, Rennes, 30th July 2017.

yap1 is expressd in Müller cell of the retina in Xenpus and in mouse.

yap1 is required for cell cycle reentry of Müller cells after injury.

yap1 controls retinal stem cell DNA replication timing and genomic stablility.

summary from NCBI

This gene encodes a downstream nuclear effector of the Hippo signaling pathway which is involved in development, growth, repair, and homeostasis. This gene is known to play a role in the development and progression of multiple cancers as a transcriptional regulator of this signaling pathway and may function as a potential target for cancer treatment. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Aug 2013]