XB-FEAT-965579

tlcd3a

This is the community wiki page for the gene tlcd3a please feel free to add any information that is relevant to this gene that is not already captured elsewhere in Xenbase.

nomenclature changes

05.13.19

Human symbol has changed for genepage ID: 965579 From fam57a to tlcd3a

Human symbol has changed for Entrez Gene: 79850. From FAM57A to TLCD3A

Human name has changed for Entrez Gene: 79850. From family with sequence similarity 57 member A to TLC domain containing 3A

Summary from NCBI for human TLCD3A

The protein encoded by this gene is a membrane-associated protein that promotes lung carcinogenesis. The encoded protein may be involved in amino acid transport and glutathione metabolism since it can interact with a solute carrier family member (SLC3A2) and an isoform of gamma-glutamyltranspeptidase-like 3. An alternatively spliced variant encoding a protein that lacks a 32 aa internal segment showed the opposite effect, inhibiting lung cancer cell growth. Knockdown of this gene also inhibited lung carcinogenesis and tumor cell growth. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2015]