Small Molecules for Xenopus Research

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Important small molecule references

• Database of Small Molecules by Feldman and Hogue 2006 at PubChem
• Wnt/Notch by Myers and Krieg 2014
• Ubiquitin-proteasome by Salic and King 2005

Alphabetical List of Small Molecules With Literature References

• 1,3-Dicyclohexylurea
• 11-cis retinal
• 18alpha-glycyrretinic acid
• 2'-deoxyadenosine
• 2-APB
• 3,3,5-triiodothyronine (T3)
• 5HT (seratonin)
• activin
• AG1296
• AG1879
• AGN193109
• alpha-amanitin
• anandamide
• apelin
• aphidicolin
• AZD1480
• Bafilomycin A1
• BAPTA-AM
• Barasertib
• Benzaldehyde, 3-allyl-2-(2-(diethylamino)ethoxy)-(DEAB)
• beta-xyloside
• blebbistatin
• BMS-453
• bumetanide
• calcium ionophore
• CGP54626
• Chelerythrine
• chenodeoxycholic acid
• chymostatin
• Citral
• Colcemide
• concanamycin
• cycloheximide
• cyclopamine
• Cyclosporin A
• Cytochalasin B
• cytochalasin D
• D-AP5
• D-NAME
• Demecolcine
• deltamethrin
• dexamethosone
• DHT(dihydrotestosterone)
• diazepam
• Difopein
• Diphenyleneiodonium Chloride
• DMH-1
• Dorsomorphin
• DRB
• Ex-527
• finasteride
• folic acid
• forskolin
• fusicoccin
• gentamycin
• GSK3-inhibitor IX (BIO)
• GM6001
• heptanol
• herbimycin A
• Hydroxyurea
• IBMX
• jasplakinolide
• 6-B345TTQ
• KT 5720
• L-NAME
• lansoprazole
• latrunculin B
• LDN-193189
• leucovorin
• LiCl
• LY294002
• methotrexate (MTX)
• metronidazole
• Mg132
• MMP-2 inhibitor II
• MS-275
• nicorandil
• Nicotinamide
• Nicotinic acid
• nifedipine
• nocodazole
• NSC-87877
• o-phenanthroline
• okadaic acid
• olomoucine
• ouabain
• PD173074
• PD-407824
• p-MPPI
• Paclitaxel
• phaclofen
• Picropodophyllin
• PMA
• PP2
• primaquine
• Progesterone
• propylthiouracil
• pyrimethamine
• quinpirole
• rac1 inhibitor
• rapamycin
• retinoic acid
• Retinol
• RO-3306
• RS67333
• RU486
• SAHA
• SB 203580
• SB431542
• SB 505124
• SCH28080
• SNAP
• sodium nitroprusside
• SP600125
• SU5402
• SU6656
• Suramin
• tautomycin
• taxol
• thyroxine (T4)
• Torin 2
• Trichostatin A
• trimetrexate
• TTNPB
• Tubercidin
• tunicamycin
• Tyrphostin AG 1478
• U73122
• Y27632
• ZM 447439

The Following are in need of standardization and curation

• AM251
• AM281
• AP1510
• AR-A014418
• BHQ
• b-aminoproprionitrile
• beclomethasone
• Butyrate
• calcicludine
• Calyculin A
• celastrol
• celecoxib
• chromanol 293B
• chlorate
• cytochalasin D
• colchicine
• dimethyloxallyl glycine (DMOG)
• diclofenac
• etoposide
• IWR1
• GW843682X
• leptomycin B
• LY320135
• methylcellulose (MC)
• methimazole
• MBCD or MBetaCD
• MS222
• nicardipine
• Nu6102
• phenylthiourea (PTU)
• purmorphamine
• Pyrazoleanthrone
• R(+)BayK 8644
• RHC80267
• RL-3
• SAG
• SB-431542
• TG003
• Thapsigargin
• U0126
• ursodeoxycholic acid
• Echinomycin
• Gö 6983
• phenylhydrazine
• ω-conotoxin–GVIA
• flunarizine
• tetrodotoxin
• veratridine
• NBI-27914

Small Molecules Affecting Pathways

cAMP

• IBMX
• RU486

CDK/Cyclins

• olomoucine
• RO-3306

ERK/MAPK

• U0126

Folic Acid

• Methotrexate (MTX)

JAK/STAT

• AZD1480

JNK

• SP600125
• Pyrazoleanthrone

Nitric Oxide

• sodium nitroprusside

PDGF

• AG1296
• AP1510

Retinoic Acid

• AGN193109
• Citral
• retinoic acid
• Retinol
• TTNPB
• BMS-453

Shh

• cyclopamine
• purmorphamine
• Vismodegib

TGF-beta/BMP

• SB-431542
• SB505124

Thyroid Signaling

• PTU

Wnt

• LiCl
• GSK3-inhibitor IX (BIO)
• IWR1

Epigenetics

• Ex-527

Protease Inhibitors

• chymostatin
• GM6001 (MMP inhibitor)
• o-phenanthroline(MMP inhibitor)
• BB-94 MMP inhibitor
• GI254023X MMP10 inhibitor

Small Molecules affecting Biological Functions & Processes

Angiogenesis

• dimethyloxallyl glycine (DMOG)
• herbimycin A
• Suramin

Apoptosis

• cycloheximide
• alpha-amanitin
• Cyclosporin A
• 2,2ʹ-Methylenebis(1,3-cyclohexanedione)
• NS3694

Autophagy

• LY-294002

Calcium Signaling

• nifedipine
• R(+)BayK 8644
• nicardipine
• deltamethrin
• BHQ
• Thapsigargin

Circadian Rhythm

• quinpirole

Cytoskeletal Inhibitors

• Cytochalasin B
• cytochalasin D
• Colcemide
• jasplakinolide is an activator
• latrunculin B
• taxol
• Paclitaxel

Cell Cycle, including mitosis

• Colcemide
• Hydroxyurea
• olomoucine
• PD-407824

Cilia

• methylcellulose (MC)

DNA Damage/Repair

• etoposide
• Hydroxyurea

DNA Synthesis

• Calyculin A

Growth Cone, Filopodia, and other Cytoskeletal projections

• PP2
• SU6656
• cytochalasin D 0.1 uM Sigma
• latrunculin B 30nM Sigma
• colchicine 12.5uM Sigma
• nocodazole 0.1uM Sigma
• RHC80267

Hatching

• ouabain

Left-Right Patterning

• methylcellulose (MC)

Metamorphosis

• 3,3,5-triiodothyronine (T3)
• methimazole
• propylthiouracil
• thyroxine (T4)

Neurotransmission

• diazepam
• p-MPPI
• phaclofen
• RS67333
• deltamethrin

Protein Recycling

• primaquine

Drugs by Gene Class

Channels, including ATPases

• ouabain
• AM251
• AM281
• LY320135

G Protein Receptors

• purmorphamine

Kinases

• KT 5720
• olomoucine
• PD-407824
• SB 203580
• Y27632
• ZM 447439

Phosphatases

• Cyclosporin A
• deltamethrin
• okadaic acid
• tautomycin
• Calyculin A

Protein Synthesis

• anisomycin 40uM Sigma
• cycloheximide 40uM

Retinoids

• TTNPB Sigma

Textpresso Small Molecules to Research

• importazole inhibits importin
• M119
• GBG or GBetaGamma or G Protein Beta Gamma
• LY-294002 inhibits PI3K and autophagy

Models of Anemia

• Phenylhydrazine