ZM 447439

Description

"Novel, selective ATP-competitive inhibitor of Aurora B kinase in vitro (IC50 values are 50, 250 and 1000 nM for Aurora B, C and A kinases respectively). Selective over a range of other kinases including cdk1 and PLK1 (IC50 > 10 μM). Inhibits cell division and displays selective toxicity towards proliferating tumor cells versus non-dividing cells."

• -Tocris product description

ZM 447439 structure, photo from Pubchem

Genes Affected

• aurkb

Suppliers

• EMD Millipore
• Tocris
• Selleck
• Santa Cruz
• Cayman
• Enzo

Usage Notes

20uM

References

• Pubchem
• Edens et al., 2014
• [1]

>1 Xenbase articles contain a reference to ZM 447439 according to textpresso

• Back To Small Molecules Home Page