Latrunculin A

Description

"Latrunculin A is a bicyclic macrolide natural product consisting of a 16-membered bicyclic lactone attached to the rare 2-thiazolidinone moiety. It is obtained from the Red Sea sponge Latrunculia magnifica and from the Fiji Islands sponge Cacospongia mycofijiensis. Latrunculin A inhibits actin polymerisation, microfilament organsation and microfilament-mediated processes. It has a role as a toxin, a metabolite and an actin polymerisation inhibitor. It is a cyclic hemiketal, an oxabicycloalkane, a thiazolidinone and a macrolide". Source: [ http://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:69136]

structure, image from PubChem

Alternative names

• LAT-A
• Lata
• Latrunculin-A

References

• [1]
• NCBI PubChem CID:445420

> 4 Xenbase articles contain a reference to Latrunculin-A according to textpresso

• Back To Small Molecules Home Page