XB-FEAT-12565069
ptprn2
nomenclature changes
05.13.19 Human name has changed for Entrez Gene: 5779. From protein tyrosine phosphatase, receptor type N2 to protein tyrosine phosphatase receptor type N2
Summary from NCBI for humanPTPRN2
This gene encodes a protein with sequence similarity to receptor-like protein tyrosine phosphatases. However, tyrosine phosphatase activity has not been experimentally validated for this protein. Studies of the rat ortholog suggest that the encoded protein may instead function as a phosphatidylinositol phosphatase with the ability to dephosphorylate phosphatidylinositol 3-phosphate and phosphatidylinositol 4,5-diphosphate, and this function may be involved in the regulation of insulin secretion. This protein has been identified as an autoantigen in insulin-dependent diabetes mellitus. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2015]