XB-FEAT-22172617

nomenclature updates

12.31.2019

This gene page was created after a review by David Webb from the NCBI and Xenbase curators.

A synteny analysis of ripk3 genes identified this gene ( Entrez gene ID: 100497374) as the Xenopus tropicalis orthologue of human RIPK3 as its location and gene order is conserved across taxa.

In humans, frog, lizard and turtles, it is found in this gene order: nfatc4> ripk3> adcy4>.

In Xenopus tropicalis and X. laevis, ripk3 is on Chromosome 1, and chromosome 1.L respectively.

The 2 other ripk3 genes from earlier genome builds are not the true orthologues of human RIPK3, and have been renamed as like genes.

In X. tropicalis, ripk3-like gene 1 is on currently placed on Chr2, and in X. Laevis, ripk3-like gene 1.L it is on Chromosome 8.L, although this needs more study to determine for sure.

Currently, there is no model for ripk3l.2.S ( watch this space!)

It seems that the ripk3l.1 and ripk3l.2 genes do not occur in other vertebrates except the caecillian (Rhinatrema bivittatum), and may represent an amphibian-specific gene duplication event.