XB-FEAT-22166511

gpr151

This is the community wiki page for the gene gpr151 please feel free to add any information that is relevant to this gene that is not already captured elsewhere in Xenbase.

nomenclature changes

04JAN2023

gene name changed from provisional ortholog of G protein-coupled receptor 151 to G protein-coupled receptor 151

gene symbol changed from XB22166511 to gpr151

summary for human GPR151 from NCBI

This gene encodes an orphan member of the class A rhodopsin-like family of G-protein-coupled receptors (GPCRs). Within the rhodopsin-like family, this gene is a member of the SOG subfamily that includes somatostatin, opioid, galanin, and kisspeptin receptors. The orthologous mouse gene has a restricted pattern of neuronal expression which is induced following nerve injury. All GPCRs have a transmembrane domain that includes seven transmembrane alpha-helices. A general feature of GPCR signaling is the agonist-induced conformational change in the receptor, leading to activation of the heterotrimeric G protein. The activated G protein then binds to and activates numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes. [provided by RefSeq, Jul 2017]

synteny is conserved across vertebrtate taxa

human: TCERG1> ... GPR151<< ... CTB-99A3.1> ... PPP2R2B<

mouse: Tcerg1> ... Gpr151< ... Ppp2r2b<

zfish: exosc3< ... tcerrg1a> ...gpr151< ... ppp2r2ba<

X. tropicalis: pou4f3> ... tcerg1> ... gpr151< ... ppp2r2b

(not found in Chicken)