XB-FEAT-5839287

fucolectin-e

This is the community wiki page for the gene fucolectin-e please feel free to add any information that is relevant to this gene that is not already captured elsewhere in Xenbase

nomenclature changes

2FEB2023 this gene is poorly annoated and named.

Xenbase curators are currently reviewing all gens annotated as Xenopus fucolectins.

provisional changes:

the gene name and gene symbols are the wrong way around, so gene symbol has been changed from fucolectin to fucolectin e with gene name epidermal fucolectin, and gene symbol 'x-epilectin' will be recorded as a synonym,as we don't use any reference ro xenopus (x) in gene names .

original description of this protein coding gene

Int J Dev Biol. 2004 Dec;48(10):1119-29.

doi: 10.1387/ijdb.041892km

X-epilectin: a novel epidermal fucolectin regulated by BMP signalling

Karine Massé 1, Rebecca Baldwin, Mark W Barnett, Elizabeth A Jones

PMID: 15602698 DOI: 10.1387/ijdb.041892km

Abstract

This paper reports the cloning and characterisation of a new posterior epidermal marker, X-epilectin, in Xenopus laevis. This gene encodes for a fucolectin, which belongs to the lectin superfamily of carbohydrate binding proteins and specifically binds fucose residues. RT-PCR and in situ hybridisation show that the expression of this gene is switched on during gastrulation and up-regulated during neurula stages and found expressed ubiquitously throughout the epidermis. From tailbud stages, the expression is limited to the dorsal posterior region of the embryo, suggesting that X-epilectin expression is regulated along anteroposterior and dorsoventral gradients during development. In the adult, X-epilectin is mainly expressed in intestinal components, kidney, spinal cord and skin. The effects of growth factors on the regulation of X-epilectin were studied. Change of the fate of animal caps into cement gland or dorsal mesoderm induces a down-regulation of X-epilectin expression in explants treated respectively with ammonium chloride and activin A. We also show that X-epilectin expression is down-regulated by Noggin and tBR and that this effect is inhibited by BMP4 over-expression, suggesting X-epilectin expression is mediated by the BMP signalling pathway.