XB-FEAT-5953480

cupin1

This is the community wiki page for the gene cupin1 please feel free to add any information that is relevant to this gene that is not already captured elsewhere in Xenbase.

nomenclature changes and synteny

09FEB2023

Xenopus dynap gene is found on chromosome 1/1L/1S in Xenopus, and is the ancestral 9-exon gene that is ~475 aa in all taxa (473aa in Xenopus) and having a N-terminal CLLAC domain and either a C-terminal bicupin_oxalic or two CUPIN_1 domains. This is the ancestral "DYNAP" gene is found in birds, reptiles, amphibians, mammals and all the way back to sharks like Callorhinchus milii.

NOTE that DYNAP genes are flanked by C18orf54 and RAB27b.

In X. tropicalis and X. laevis.L subgenome, there is a 2nd duplicated dynap gene (we will called it dynap.2) which also has a 9 exons, and codes for a slightly shorter 471aa protein, and it is absent from Xlaevis S subgenome. Following the synteny pattern for true DYNAP orthologs, we have named the gene closest to c1h18orf54 ( the ortholog of C18orf54) dynap, and the duplicated gene next to rab27b, dynap.2.

We take infer that as it has the same 9-exon structure it is a duplicated gene, a common enough occurance in Xenopus. HGNC note that there is often a 2nd 5-exon DYNAP gene or pseudogene in cow, dog, cat, shrew, opossum, and koala, but there is no sign of this shorter gene in the v10 Xenopus genome annotations.

synteny patterns:

Xtrop: ccdc68> ... rab27b> ... dynap.2< ... LOC116408353(lnRNA)> ... dynap< ... c1h18orf54< ...stard6<

Xla.L: ccdc68.L> ... rab27b.L> ... dynap.2.L< ... dynap< ... c1h18orf54.L< ...stard6.L<

Xla.L:ccdc68.S> ... rab27b.S> ... dynap.S< ... c1h18orf54.S< ...stard6.S<

dynap.2 gene IDs:

Xtrop dynap.2 NCBI gene ID:100485626

Xla dynap.2.L NCBI gene ID:108695867