XB-FEAT-6071789

flt1

This is the community wiki page for the gene flt1 please feel free to add any information that is relevant to this gene that is not already captured elsewhere in Xenbase

orthology and synteny notes

04APRIL2023

Despite suggestions from DIOPT Analysis, this gene is not orthologous with human KDRL.

In Xtrop and in Zebrafish, kdrl is adjacent to chic1 and cdx4, whereas flt1 is flanked by slc46a3 and pan3

There does not appear to be an orthologous human gene for flt1 ( I missing in human and other mammals)

synteny of flt1 versus kdr1

Synteny across Xenopus is highly conserved for flt1:

Xtrop: mtus2 > [LOC#9015(p) LOC#9139(unch) LOC(unch) LOC#9957] flt1> pan3< flt3>

Xla.L : mtus2.L > slc46a3.L flt1.L> pan3.L< flt3.L>

Xla.S : mtus2.S > slc46a3.S flt1.S> pan3.S< flt3.S>