XB-FEAT-22065609

sprtnl2

This is the community wiki page for sprtnl2 - please feel free to add any information that is relevant to this gene that is not already captured elsewhere in Xenbase.

nomenclature changes

05JAN2023

Xenopus gene name changed from provisional ortholog of SprT-like N-terminal domain to SprT-like N-terminal domain like gene 2 (provisional)

Xenopus gene symbol changed from XB22065609 [provisional:sprtn] to sprtnl2.

both gene name and symbol are (provisional) awaiting HGNC/NCBI Ref Seq approval.

25April2023

Xenopus gene symbol changed from sprtnl2 to sprtnl.2 as RefSeq suggested, not giving this gene a Xenopus only numerical suffix, as it would never propogate through to other species, so we applied Xenopus nomenclature and the 'gene 2'suffix.

synteny

X. laevis sprtn.S on Chromosome 5.S seems to be the true orthology of human SPRTN, with both being flanked by eglin1 and exoc8.

Human chr 1: RNA5SP80< ... EXOC8< ... SPRTN> ...LOC107985360> ... EGLN1< ...LOC122152336>

X. laevis chr5.S: sf3b5.S< ... exoc8.S< ...tsnax.S< ... egln1.S< .. sprtn.S> ... acta1.S< ... LOC108717893< ...

the 2 other X. tropicalis genes have been given provisional names sprtn2 [geneID: 105945677) and sprtn3 [geneID: 105948375]

X. trop chr1: jsprp1> ...amh< ...sf3a2< ... plekhj1> ... dot1l> ... 'sprtnl2'> ... ap3d1> ... mob3a> ... mknk2> ... btbd2> ... csnk1g2< ...

X. trop chr9: gng13> ... chtf18< ... rpusd1> ... msin< ... 'sprtnl3'< ... LOC#3326> ... LOC#3470 ...