XB-FEAT-22062350

nat2

This is the community wiki page for the gene nat2 please feel free to add any information that is relevant to this gene that is not already captured elsewhere in Xenbase.

nomenclature changes

Xenopus gene symbol/name changed from XB22062350 [provisional:nat2], to nat2, N-acetyltransferase 2.

orthology

DIOPT/EggNog analysis of the Xtrop protein confirms that this gene is a N-acetyltransferase, matching it to >1500 proteins in over 1200 species.

Further comparison of synteny required to determine if it is the true ortholog of human NAT2, as NCBi only lists mammalian orthologs. It may be better called nat1?

protein used in orthology analysis

arylamine N-acetyltransferase 2 isoform X1 [Xenopus tropicalis] NCBI Reference Sequence: XP_004915070.1

>XP_004915070.1 arylamine N-acetyltransferase 2 isoform X1 [Xenopus tropicalis] MVPTTCIMSTLQIGSFRLHVSVICALPPALCSAYTTPPHYIQLLPSIHNPSPLQTAPPLYTQLLPEFNFH FGCPRWGKICDCSAGVGRMDLKGYLHRVGLSTQKPPSLTALRELHHRHLLSVPFGSLGIHSGERIILDHT LLYDKIVVRRQDGFCYENNGLFLWVLRESGYQPVVLSARVCNSITGVYGPPYDHMILAVELEGQRWLCDV GFGEGIAFPIPLEAGWEGEHPSGVFRLQKAEEEWYLERKEDGGWRSLYKFRLEEKRFEDFRDMCDYHQMS PSSIFFCKSFCSLLLPRGRATYMGCRLISTEYTAGGGTVKSTTELTEGEIPRVLRETFGIVLNGKLVPKD EPIVPPECD