XB-FEAT-6257460

trim26

This is the community wiki page for the gene trim26 please feel free to add any information that is relevant to this gene that is not already captured elsewhere in Xenbase

nomenclature changes

06.30.2020

Human symbol has changed for genepage ID: 6257460 From trpm2l to trim26

Human symbol has changed for genepage ID: 6257460 From transient receptor potential cation channel, subfamily M, member 2 like to tripartite motif containing 26

1MAY2023

Synteny (below) does not support the orthology between Xenopus and human trim26/TRIM26, and NCBI orthology analysis also does not identify Xtrop Gene ID:100491139 as an ortholog of TRIM26. Thus we conclude that this gene has been misannotated and incorrectly named trim26.

XB Action: removed the vertebrate orthologs for TRIM26 from this gene page, and renamed these genes trpm2l, transient receptor potential cation channel, subfamily M, member 2 like

Synteny as of April 29th, 2023

Human: TRIM 10 ... TRIM15 ...PAIP1P1 ... TRIM26 ... TRIM26BP ... HCG17

XTR.chr2: ilk ... tpp1 ... 'trim26' ... zscan2

Xla.chr2L: dynp1 ... rrp8.L... mgc822989 ...tpp1 ...tif-if2 ...'trim26' .. zfp391

Human chr21: ICOSLG< ... DNMT3L.... AIRE.... PFKL>.... CFAP410. TRPM2 ... LRRC3 ... TSPEAR ... UGE2G2< SUMO3. PTTG1IP< ... ITGB2<.... SLX9>

summary for human TRIM26 from NCBI

The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The protein localizes to cytoplasmic bodies. Although the function of the protein is unknown, the RING domain suggests that the protein may have DNA-binding activity. The gene localizes to the major histocompatibility complex (MHC) class I region on chromosome 6. Alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jun 2011]