XB-FEAT-12564498

col11a2

This is the community wiki page for the gene col11a2' please feel free to add any information that is relevant to this gene that is not already captured elsewhere in Xenbase.

nomenclature changes

01MAY2023

Xenopus gene symbol was changed from col11a2 to col11a2.2

Xenopus gene name was changed from collagen type XI alpha 2 chain to collagen type XI alpha 2 chain gene 2

orthology and synteny

1MAY2023

2 different 'collagen type XI alpha 2 chain' genes are annotated on Chromosome 8 in the v10 X. tropicalis genome:

1) GeneID:100488265 (not represented on a Xenbase genepage)

2) GeneID:448277 on this gene page XB-GENEPAGE-12564498

Synteny supports the X. tropicalis GeneID:448277 as the true ortholog of human COL11A2, as it is flanked by a MHC-gene and rxrb:

Synteny:

HUMAN Chr6: LOC(UNCH)< MHC/HLA-DPA3> HCG24> COL11A2< RXRB< SLC39A7>

X.tropChr8 GeneID:100488265: kifcl< mgc147402< rxrb> col11a2> mhc-dab< loc100487257<

X.tropChr8 GeneID:448277: loc(ficolin1b) loc(ficolin1b-like) col11a2> Xb5814630 loc(inkt) loc(nnmt)

This indicates the need for nomenclature change for X.trop GeneID:448277 from col11a2 to col11a2.2, and a new gene page (requested) for the true col11a2!